Prevalence of raised mean platelet volume in patients of chronic plaque psoriasis

Platelet volume in patients of chronic plaque psoriasis

Abstract

BACKGROUND & OBJECTIVE: Psoriasis is a systemic, chronic autoimmune inflammatory disorder. MPV is a useful metric for assessing platelet aggregation and activity. To determine the mean platelet volume (MPV) in patients of chronic plaque psoriasis.

METHODOLOGY: This cross-sectional study was conducted in the Dermatology Department at Allied II Hospital, Faisalabad Medical University, Faisalabad. A total of 175 patients aged 18 to 50 years with clinically confirmed persistent plaque psoriasis were included in the study. Patients with comorbidities that impacted platelet function were excluded from the study.

RESULTS: Among 175 patients, 58 (33.1%) had raised MPV. Mean MPV was 8.61 ± 0.69 fL. The majority had severe psoriasis (60.6%) and were overweight (62.3% with BMI >25). No statistically significant association was found between MPV status and age (p=0.254), gender (p=0.359), BMI (p=0.709), disease duration (p=0.758), or PASI-based disease severity (p=0.801).

CONCLUSION: A substantial proportion (33.1%) of patients with chronic plaque psoriasis had elevated MPV, with a mean value of 8.61 ± 0.69 fL, indicating increased platelet activation. However, no significant association was observed between MPV and disease severity or other clinical variables. MPV may reflect systemic inflammation, but it is not reliably related to psoriasis severity.